Arthritis can arise from various factors, including overuse leading to joint wear and tear, particularly common in occupations or activities that involve repetitive motions. Age plays a significant role, as joints undergo wear and tear over time. Injuries, Obesity, Genetics and family history also might be the cause of your arthritis. Certain autoimmune disorders, such as rheumatoid arthritis, result from the immune system attacking joint tissues, leading to inflammation and joint damage.